One Silicon Valley entrepreneur thought he could beat the odds. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Some people report mild nausea while on the drug (stops when stop the drug). In other cases, stop cold turkey. I couldnt tell I was on the drug. CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. But they dont want their names used. Added to FLCCC protocols and Fareed-Tyson protocol among others. Once the Phase 2 result came out, it should have been embraced by doctors. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. This give another 50% of benefit. Hilary Grant-Valdez Operations Manager Tom Brunner I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. Both of them encouraged anyone reading this article to get vaccinated. Do they sell it anywhere? While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. more time. May 16, 2022. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. and increased heart rate (which could be nerves about the dilated pupils). Part of TV News Archive. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. Food/drugs to avoid while on fluvoxamine. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. Proxalutamide and fluvoxamine pushers and the early treatment grift. It was tested in. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . So you can address your OCD and if you get COVID, youll can up the dose. Fluvoxamine, COVID, pandemic, . Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . That was a big mistake because the original paper contained text related to earlier studies and the editors chopped it out. I took it myself at that dosage and noticed zero side effects. I took it myself at that dosage and noticed zero side effects. How can we get fluvoxamine? We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. It doesnt get much better than that. You will be wired for 24 hours if you dont heed my advice. If you take fluvoxamine, please avoid caffeine while on the drug. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. Telling the truth, he tweeted. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Im taking low dosage Fluvoxamine as part of a multi-drug FLCCC protocol to alleviate some mild brain fog. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Reason is the hospital gets release from liability if they follow NIH guidelines. They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. I must admit that this is an anniversary that snuck 90,000 people don't have to die in the next 3 weeks. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. He has a history of giving away some of his millions to good causes, and when COVID-19 began. In-patient use. 47).. All have had a 100% success record in keeping their patients out of the hospital. If you start later, doctors use higher dosages and compliance becomes a bigger problem. just like ivermectin). My experience is very typical. Now weve lost the high ground, Morris told me. . This is the gold standard of evidence based medicine. They never make things worse so are safe to try. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. Lack of action. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. Hes very convincing. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. The medical community did nothing (with a few exceptions like Dr. Seftel). Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. We need to keep people out of the hospital in the first place. Steve Kirsch. Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. . People who report not tolerating the drug are typically prescribed too high a dose. It used to be that a Phase 3 study would do it. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. Mar. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. I mean, he really, truly has a heart of gold, Char told me. It does not matter how many lives will be saved. Its the gold standard of medical evidence. One is to reduce the threat of nuclear war. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. NIH is still unsure whether fluvoxamine should be used to treat COVID. It is perhaps the greatest unnecessary loss of life in American history. Most recent articles first. See more below. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Theres nothing there.). He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. The infectious disease scientists lied to me. Note that some of these articles are inaccurate. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. The NIH wrote a bullshit rejection because the FDA told them not to approve it. 95% confidence effect size is 75% or more. It is very important to educate doctors because most people rely on their doctors for advice. If you cant get a prescription for COVID, then perhaps you have OCD? And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? He retired at the largest pension in federal history. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. Most doctors wont use it until NIH greenlights it, no matter what the science says. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. I will . But even she was drained by Kirschs constant attempts to override the data. Long haul. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. 33. Everyone says "we need more data" to show fluvoxamine works for COVID. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Get your prescription in advance of getting COVID. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. Hes spending his own money to do what he thinks is right. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. Dosage there is 30mg once a day. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Fluoxetine is just as effective. Early treatment with existing drugs is the fastest, most effective, and lowest. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . Silence from the medical community. If you take fluvoxamine, please avoid caffeine while on the drug. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. You can help by bringing this document to your doctor's attention. Who knows, Morris replied. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. @stkirsch. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). We should be making decisions now based on the evidence on the table today. Summarizes the 5 observational studies, RCT, RWE, and some of the more interesting anecdotal data. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? 21. Some are views most scientists think are wrong. It used to be that a Phase 3 study would do it. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Compulsive fiddling with your mask? The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. I wanted to get the article out before my flight left. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. The 5 observational studies is icing on the cake. There are 4 outpatient studies that have been done (2 at WashU (see. There are at least eight mechanisms of action that we think contribute to the effectiveness of this drug. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. . We could have saved a lot of lives. If you cant lay off the java, then try fluoxetine (Prozac). The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. I was just getting tired, he said, before asking to speak off the record. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. Most recent articles first. He may not be a good scientist, but hes smart, says WVUs Feinberg. If you cant get a prescription for COVID, then perhaps you have OCD? There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). This looks ominous, but it harmless. Steve Kirsch is a Silicon Valley philanthropist. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. All can merit a fluvoxamine prescription based on traditional diagnoses. That is when the phase 2 results were published. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. See the repository above. Fluvoxamine has a 40 year safety track record. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. That is when the phase 2 results were published. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. (Clayton Fox, Marty Makary, and Jeffrey Klausner). The incident, he added, was completely in keeping with his personality.. Here is the latest version. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. No long haul symptoms if you start the drug ASAP after first symptoms. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Their willingness to lie did. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. 533. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. I couldn't agree more. That covers almost 150,000 of them, which happened before vaccinations began. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. Skirsch.io traffic volume is 1,957 unique daily visitors and their 3,914 pageviews. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. I fixed the link to the fluvoxamine article. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. Keeping this drug off the NIH Guidelines does nothing to reduce the death rate. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). The web price charge of skirsch.io . They immediately ruled out the vaccine, because the vaccine is, quote, safe.. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Stopping the meds will return you to your normal self. The sooner you start, the better the outcomes. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. Twenty-four years ago, . . Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. Links to evidence about fluvoxamine including the public data repository. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Steve Kirsch. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). . They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Compulsive hand washing? It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. A video presentation by Steve Kirsch, Executive Director of the Covid-19 Early Treatment Fund. Mouse Systems is not a household word, he told the journalist. It never was. I think we did rigorous reviews of proposals for research.. I only know of a few doctors who prescribe this off-label, all with 100% success rates. That receptor also helps regulate the body's . Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. Here are the key things you should know about fluvoxamine for COVID: It works. All the researchers are convinced the drug works. He was recently featured on 60 Minutes, . Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". The NIH never did a risk benefit analysis of this drug. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Be warned!. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. Consider masks by contrast. The study was also featured on 60 Minutes. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. Zero. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. Note that a total of 77 people got the drug, not 65. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. It will be months before enrollments are complete. If you start 5 days after symptoms, all bets are off. . including the very promising Fluvoxamine. Medicine isnt about saving lives anymore. Read More fluvoxamine The Fluvoxamine FAQ And that is what has allowed Kirsch, and people like him, to become so influential. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. His foundation shifted focus to one goalcuring Steve Kirschby supporting one of the few scientists looking at the disease. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms.